[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-
PF-9366
CAS: 72882-78-1
Molecular Formula: C20H19ClN4
[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl- - Names and Identifiers
| Name | PF-9366 |
| Synonyms | CS-2703 PF9366 PF-9366 PF 9366 72882-78-1 PF 9366 NEW [1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl- |
| CAS | 72882-78-1 |
[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl- - Physico-chemical Properties
| Molecular Formula | C20H19ClN4 |
| Molar Mass | 350.84 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Melting Point | 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
| Solubility | DMSO : 25 mg/mL (71.26 mM; Need ultrasonic) |
| Appearance | solid |
| Color | Beige |
| pKa | 8.75±0.28(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | PF-9366 is a Mat2A inhibitor with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 there was no substantial off-target activity in GPCR, neural transporters, phosphodiesterases and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibition of cellular S-adenosyl-L-methionine (SAM) in H520 lung cancer cells gave an IC50 of 1.2 μm. PF-9366 was more potent for SAM synthesis in Huh-7 cells with an IC50 of 255 nM and also inhibited cell proliferation with an IC50 of 10 μm. |
[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.85 ml | 14.252 ml | 28.503 ml |
| 5 mM | 0.57 ml | 2.85 ml | 5.701 ml |
| 10 mM | 0.285 ml | 1.425 ml | 2.85 ml |
| 5 mM | 0.057 ml | 0.285 ml | 0.57 ml |
Last Update：2024-01-02 23:10:35
[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl- - Reference Information
| Introduction | PF-9366 is a human metagonine adenosyltransferase 2A (Mat2A) inhibitor with IC50 value of 420 nM, the Kd value was 170 nM. |
| in vitro study | PF-9366 is a Mat2A inhibitor with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 there was no substantial off-target activity in GPCR, neural transporters, phosphodiesterases and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibition of cellular S-adenosyl-L-methionine (SAM) in H520 lung cancer cells gave an IC50 of 1.2 μm. PF-9366 was more potent for SAM synthesis in Huh-7 cells with an IC50 of 255 nM and also inhibited cell proliferation with an IC50 of 10 μm. |
| biological activity | PF-9366 is a human metagonine adenosyltransferase 2A (Mat2A) inhibitor with IC50 value of 420 nM, the Kd value was 170 nM. |
| Target | TargetValue hMat2A (Cell-free assay) 170 nM(Kd) hMat2A (Cell-free assay) 420 nM |
| Target | Value |
| hMat2A (Cell-free assay) | 170 nM(Kd) 420 nM |
Last Update：2024-04-09 20:52:54
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QQ: 3008007409
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Spot supply
Product Name: PF-9366 Visit Supplier Webpage Request for quotationCAS: 72882-78-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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